Southern Style Meatloaf Sandwich

Sink your teeth into the ultimate comfort food with this Southern Style Meatloaf Sandwich, a delicious twist on a timeless classic. Made with a rich blend of ground beef and pork, this meatloaf is flavored with aromatic spices, sautéed vegetables, and a tangy homemade glaze of ketchup, mustard, and brown sugar. The tender, smoky-sweet slices are tucked between soft white sandwich bread or buttery brioche buns, slathered with creamy mayo, and topped with crisp lettuce, juicy tomato, and optional tangy pickles for a perfectly balanced bite. Ready in just over an hour, this hearty recipe is ideal for lunch, dinner, or any time you’re craving a taste of the South. Pair it with a side of fries or coleslaw for an irresistible meal! Perfect for fans of classic comfort food, this recipe captures the heart of Southern home cooking in sandwich form.

Nutriscore Rating: 63/100

Prep Time:20 mins

Cook Time:60 mins

Total Time:80 mins

Servings: 4

Ingredients

• 1 lb Ground beef (80/20 blend)
• 0.5 lb Ground pork
• 0.5 cup Panko breadcrumbs
• 0.25 cup Milk
• 1 large Egg
• 0.5 cup Yellow onion, finely diced
• 0.25 cup Green bell pepper, finely diced
• 1 tsp Garlic powder
• 0.5 tsp Smoked paprika
• 1 tsp Salt
• 0.5 tsp Black pepper
• 0.25 cup Ketchup
• 1 tbsp Yellow mustard
• 1 tbsp Brown sugar
• 4 slices or buns White sandwich bread or brioche buns
• 4 tbsp Mayonnaise
• 4 leaves Lettuce leaves
• 1 medium Tomato, sliced
• 0.25 cup Pickles (optional)

Directions

Step 1

Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper or lightly grease a loaf pan.

Step 2

In a small bowl, combine the panko breadcrumbs and milk. Let this mixture sit for 5 minutes to hydrate.

Step 3

In a large mixing bowl, combine the ground beef, ground pork, hydrated breadcrumbs, egg, onion, green bell pepper, garlic powder, smoked paprika, salt, and black pepper. Use your hands to mix everything evenly, being careful not to overwork the mixture.

Step 4

Transfer the meat mixture to the prepared baking sheet or loaf pan. Shape it into a loaf if using the baking sheet, and smooth the top.

Step 5

In a small bowl, whisk together the ketchup, mustard, and brown sugar to make the glaze. Brush half of the glaze over the top of the meatloaf.

Step 6

Bake the meatloaf in the preheated oven for 45-50 minutes, then remove it and brush with the remaining glaze. Return it to the oven and bake for an additional 10-15 minutes, or until the internal temperature reaches 160°F (71°C).

Step 7

Let the meatloaf rest for 10 minutes before slicing thickly for sandwiches.

Step 8

To assemble the sandwiches, spread 1 tablespoon of mayonnaise on one side of each bread slice or bun half. Layer a slice of meatloaf, lettuce, tomato, and optional pickles on the bread. Top with the second slice of bread or bun half.

Step 9

Serve immediately and enjoy your Southern Style Meatloaf Sandwich!

Nutrition Facts

Serving size	(1453.1g)

Amount per serving	% Daily Value*
Calories	3149.2

Total Fat 200.3g	0%
Saturated Fat 61.7g	0%
Polyunsaturated Fat 2.0g
Cholesterol 810.3mg	0%
Sodium 4911.5mg	0%
Total Carbohydrate 169.9g	0%
Dietary Fiber 10.1g	0%
Total Sugars 40.5g
Protein 166.5g	0%

Vitamin D 108.7IU	0%
Calcium 555.5mg	0%
Iron 17.6mg	0%
Potassium 2051.1mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 57.3%

Protein: 21.2%

Carbs: 21.6%