Savory Artichoke Chicken Casserole

Indulge in the rich, comforting flavors of this Savory Artichoke Chicken Casserole—a perfect blend of creamy, cheesy goodness and tender bites of chicken paired with tangy artichoke hearts. This hearty dish features a velvety sauce made with sour cream, cream cheese, and mozzarella, packed with aromatic garlic, Parmesan, and a hint of oregano for a flavor explosion in every bite. Topped with golden, buttery panko breadcrumbs for a satisfying crunch, this easy-to-make casserole comes together in under an hour, making it ideal for weeknight dinners or special gatherings. Serve it hot, garnished with fresh parsley, for a wholesome meal that’s sure to impress. Perfect as a main dish, this casserole is a family favorite packed with protein and bold flavor!

Nutriscore Rating: 59/100

Prep Time:20 mins

Cook Time:30 mins

Total Time:50 mins

Servings: 6

Ingredients

• 4 cups (shredded) Cooked chicken breast
• 14 oz (drained and quartered) Artichoke hearts (canned or jarred)
• 1 cup Sour cream
• 0.5 cup Mayonnaise
• 8 oz Cream cheese (softened)
• 0.5 cup Grated Parmesan cheese
• 1 cup Shredded mozzarella cheese
• 3 cloves Garlic (minced)
• 1 tsp Salt
• 0.5 tsp Black pepper
• 1 tsp Dried oregano
• 1 cup Panko breadcrumbs
• 2 tbsp Unsalted butter (melted)
• 2 tbsp Chopped fresh parsley (optional, for garnish)

Directions

Step 1

Preheat the oven to 375°F (190°C). Lightly grease a 9x13-inch casserole dish with non-stick cooking spray or butter.

Step 2

In a large mixing bowl, combine the cooked, shredded chicken and quartered artichoke hearts. Set aside.

Step 3

In a medium bowl, whisk together the sour cream, mayonnaise, softened cream cheese, grated Parmesan cheese, shredded mozzarella cheese, minced garlic, salt, black pepper, and dried oregano until well blended.

Step 4

Pour the creamy cheese mixture over the chicken and artichoke hearts. Stir until all ingredients are evenly coated.

Step 5

Transfer the mixture to the prepared casserole dish, spreading it out evenly.

Step 6

In a small bowl, combine the panko breadcrumbs with the melted butter. Mix until the breadcrumbs are evenly coated with the butter.

Step 7

Sprinkle the buttery breadcrumbs evenly over the top of the casserole.

Step 8

Bake in the preheated oven for 25-30 minutes, or until the casserole is bubbling and the breadcrumb topping is golden brown.

Step 9

Remove the casserole from the oven and let it rest for 5 minutes before serving.

Step 10

Garnish with freshly chopped parsley, if desired, and serve warm.

Nutrition Facts

Serving size	(1943.1g)

Amount per serving	% Daily Value*
Calories	4492.9

Total Fat 298.7g	0%
Saturated Fat 130.1g	0%
Polyunsaturated Fat g
Cholesterol 1239.5mg	0%
Sodium 7078.5mg	0%
Total Carbohydrate 150.8g	0%
Dietary Fiber 22.4g	0%
Total Sugars 31.2g
Protein 306.4g	0%

Vitamin D 0IU	0%
Calcium 2056.3mg	0%
Iron 14.1mg	0%
Potassium 962.7mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 59.5%

Protein: 27.1%

Carbs: 13.4%