Our Family Favorite John Wayne Casserole

Indulge in the hearty and flavorful goodness of "Our Family Favorite John Wayne Casserole," a Tex-Mex-inspired comfort food classic that’s perfect for satisfying even the hungriest crowd. This layered casserole combines seasoned ground beef, vibrant bell peppers, and zesty diced tomatoes with green chilies, all topped with a creamy sour cream and cheese blend, and finished with a golden, fluffy Bisquick biscuit crust. With optional sliced jalapeños for a spicy kick and an irresistible melted cheese topping, each bite bursts with bold flavors and rich textures. Ready in just under an hour, this easy-to-make, oven-baked dish is ideal for busy weeknights or cozy family dinners. Optimize your mealtime with this crowd-pleasing casserole that’s packed with layers of flavor and ideal for sharing!

Nutriscore Rating: 57/100

Prep Time:20 mins

Cook Time:35 mins

Total Time:55 mins

Servings: 6

Ingredients

• 1 pound ground beef
• 1 packet taco seasoning
• 0.5 cup water
• 1 cup diced onions
• 1 cup diced bell peppers (any color)
• 1 can (10 oz) canned diced tomatoes with green chilies
• 1 cup sour cream
• 0.5 cup mayonnaise
• 2 cups shredded cheddar cheese
• 1 cup shredded Monterey Jack cheese
• 2 cups bisquick mix
• 1 cup milk
• 2 eggs
• 1 for greasing dish butter or cooking spray
• 0.25 cup optional sliced jalapeños

Directions

Step 1

Preheat your oven to 350°F (175°C). Grease a 9x13-inch casserole dish with butter or cooking spray.

Step 2

In a large skillet over medium heat, brown the ground beef until fully cooked. Drain excess grease if necessary.

Step 3

Stir in the taco seasoning and 1/2 cup water. Cook for 2-3 minutes until the seasoning is well incorporated. Remove from heat and set aside.

Step 4

In a mixing bowl, combine diced onions, bell peppers, and canned diced tomatoes with green chilies. Spread this mixture evenly over the seasoned ground beef in the pan.

Step 5

In a separate bowl, mix together the sour cream, mayonnaise, 1 cup of shredded cheddar cheese, and 1 cup of shredded Monterey Jack cheese. Spread this creamy mixture over the vegetable layer.

Step 6

In another mixing bowl, prepare the biscuit crust by whisking together the Bisquick mix, milk, and eggs until smooth. Pour the mixture evenly over the casserole, spreading gently to cover.

Step 7

Top the casserole with the remaining 1 cup of shredded cheddar cheese. Add optional sliced jalapeños for extra flavor and heat.

Step 8

Bake the casserole in the preheated oven for 35-40 minutes, or until the biscuit topping is golden brown and the cheese is melted and bubbly.

Step 9

Allow the casserole to cool for 5-10 minutes before serving. Cut into portions and enjoy!

Nutrition Facts

Serving size	(2531.5g)

Amount per serving	% Daily Value*
Calories	5152.0

Total Fat 366.6g	0%
Saturated Fat 156.7g	0%
Polyunsaturated Fat 0.2g
Cholesterol 1297.2mg	0%
Sodium 11970.3mg	0%
Total Carbohydrate 292.5g	0%
Dietary Fiber 19.7g	0%
Total Sugars 73.2g
Protein 221.7g	0%

Vitamin D 247.6IU	0%
Calcium 4038.1mg	0%
Iron 26.5mg	0%
Potassium 3213.7mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 61.6%

Protein: 16.6%

Carbs: 21.8%