Missouri's Best Meatloaf

Discover the ultimate comfort food with "Missouri's Best Meatloaf," a hearty dish that combines rich flavors and simple preparation to create the perfect weeknight dinner. Made with a succulent blend of 80/20 ground beef, finely diced onions, and a touch of Worcestershire sauce, this meatloaf is kept moist and tender with breadcrumbs soaked in creamy whole milk. A tangy-sweet glaze of ketchup, brown sugar, and apple cider vinegar caramelizes beautifully during baking, giving each bite an irresistible balance of savory and sweet. Ready in just over an hour, this recipe is easy to prepare and pairs perfectly with sides like mashed potatoes or green beans for a classic, nostalgic meal. Perfect your meatloaf game with this crowd-pleaser that’s destined to become a family favorite!

Nutriscore Rating: 60/100

Prep Time:15 mins

Cook Time:60 mins

Total Time:75 mins

Servings: 6

Ingredients

• 2 pounds Ground beef (80/20 lean-to-fat ratio)
• 1 cup Breadcrumbs
• 0.5 cup Whole milk
• 1 medium Yellow onion (finely diced)
• 2 large Eggs
• 0.5 cup Ketchup
• 1 tablespoon Worcestershire sauce
• 1 teaspoon Dijon mustard
• 1 teaspoon Salt
• 0.5 teaspoon Ground black pepper
• 0.5 teaspoon Garlic powder
• 0.5 teaspoon Paprika
• 2 tablespoons Brown sugar
• 1 teaspoon Apple cider vinegar

Directions

Step 1

Preheat your oven to 375°F (190°C). Lightly grease a loaf pan or line a baking sheet with parchment paper.

Step 2

In a large mixing bowl, combine the ground beef, breadcrumbs, milk, diced onion, eggs, 2 tablespoons of ketchup, Worcestershire sauce, Dijon mustard, salt, pepper, garlic powder, and paprika.

Step 3

Mix the ingredients gently with your hands or a spatula until just combined. Be careful not to overmix, as this can make the meatloaf dense.

Step 4

Transfer the meat mixture into the prepared loaf pan or shape it into a loaf on the baking sheet. Press down slightly to create an even surface.

Step 5

In a small bowl, whisk together the remaining ketchup (about 6 tablespoons), brown sugar, and apple cider vinegar to make the glaze.

Step 6

Spread half of the glaze evenly over the top of the meatloaf. Reserve the other half for later.

Step 7

Place the meatloaf in the preheated oven and bake for 45 minutes.

Step 8

After 45 minutes, remove the meatloaf from the oven and spread the remaining glaze over the top. Return to the oven and bake for an additional 15 minutes, or until the internal temperature reaches 160°F (71°C) when measured with a meat thermometer.

Step 9

Once fully cooked, remove the meatloaf from the oven and let it rest for 10 minutes before slicing.

Step 10

Slice and serve warm with your favorite sides such as mashed potatoes, green beans, or a fresh garden salad.

Nutrition Facts

Serving size	(1518.2g)

Amount per serving	% Daily Value*
Calories	3189.0

Total Fat 205.0g	0%
Saturated Fat 78.8g	0%
Polyunsaturated Fat 0.1g
Cholesterol 1012.8mg	0%
Sodium 5671.3mg	0%
Total Carbohydrate 150.8g	0%
Dietary Fiber 6.5g	0%
Total Sugars 58.8g
Protein 185.9g	0%

Vitamin D 191.9IU	0%
Calcium 471.1mg	0%
Iron 26.2mg	0%
Potassium 2328.4mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 57.8%

Protein: 23.3%

Carbs: 18.9%