John Wayne's Favorite Casserole

Saddle up for a taste of comfort with John Wayne’s Favorite Casserole, a hearty Southwestern-inspired dish that combines bold flavors and simple preparation. Perfect for weeknight dinners or potlucks, this casserole layers a buttery biscuit base with a flavorful medley of seasoned ground beef, diced vegetables, and zesty tomatoes with green chilies. A creamy topping of sour cream, mayonnaise, and sharp cheddar cheese adds richness, while optional jalapeños bring a kick of heat for spice enthusiasts. Baked to golden perfection in just under an hour, this one-pan wonder is a crowd-pleaser you’ll return to again and again. Serve it with a fresh salad or crusty bread for a complete, satisfying meal!

Nutriscore Rating: 58/100

Prep Time:20 mins

Cook Time:45 mins

Total Time:65 mins

Servings: 6

Ingredients

• 1 pound ground beef (80/20 blend)
• 1 medium yellow onion, diced
• 1 medium green bell pepper, diced
• 10 ounces canned diced tomatoes with green chilies
• 4 ounces canned sliced jalapeños (optional, for extra spice)
• 15 ounces canned corn, drained
• 1 cup sour cream
• 1 cup mayonnaise
• 3 cups sharp cheddar cheese, shredded
• 2 cups biscuit baking mix (e.g., Bisquick)
• 1 cup milk
• 1 teaspoon salt
• 1 teaspoon black pepper
• 1 teaspoon chili powder
• 1 teaspoon cumin

Directions

Step 1

Preheat your oven to 350°F (175°C) and grease a 9x13-inch baking dish with nonstick cooking spray or butter.

Step 2

In a large skillet over medium-high heat, cook the ground beef until browned, breaking up large pieces with a wooden spoon. Drain any excess grease.

Step 3

Add the diced onion and green bell pepper to the skillet with the ground beef. Cook for 4-5 minutes, or until the vegetables soften.

Step 4

Stir in the canned diced tomatoes with green chilies, optional jalapeños, canned corn, salt, black pepper, chili powder, and cumin. Let the mixture simmer for 5 minutes to blend the flavors.

Step 5

In a medium bowl, whisk together the biscuit baking mix and milk until a soft dough forms. Spread the dough evenly across the bottom of the greased baking dish to form the base layer.

Step 6

In a small bowl, mix the sour cream, mayonnaise, and 1 cup of shredded sharp cheddar cheese. Set aside.

Step 7

Spoon the beef and vegetable mixture evenly over the biscuit dough base in the baking dish.

Step 8

Spread the sour cream and mayonnaise mixture over the beef and vegetable layer, using a spatula to create an even layer.

Step 9

Sprinkle the remaining 2 cups of shredded sharp cheddar cheese over the top of the casserole.

Step 10

Bake in the preheated oven for 35-40 minutes, or until the cheese on top is golden brown and bubbling and the biscuit layer is cooked through.

Step 11

Allow the casserole to cool for 5-10 minutes before slicing and serving.

Nutrition Facts

Serving size	(2809.1g)

Amount per serving	% Daily Value*
Calories	6254.3

Total Fat 453.5g	0%
Saturated Fat 162.9g	0%
Polyunsaturated Fat 0.2g
Cholesterol 1053.4mg	0%
Sodium 11694.8mg	0%
Total Carbohydrate 370.2g	0%
Dietary Fiber 25.3g	0%
Total Sugars 78.3g
Protein 212.0g	0%

Vitamin D 207.5IU	0%
Calcium 3700.3mg	0%
Iron 26.7mg	0%
Potassium 3925.4mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 63.7%

Protein: 13.2%

Carbs: 23.1%