Italian Beef Sandwiches with Horseradish Sauce

Sink your teeth into these mouthwatering Italian Beef Sandwiches with Horseradish Sauce—an irresistible combination of savory, slow-cooked beef, melty provolone cheese, and a zesty homemade horseradish sauce. This recipe features tender beef chuck roast, seasoned to perfection with garlic, Italian seasoning, and tangy banana peppers, all simmered low and slow for hours to create a deeply flavorful filling. Topped with creamy horseradish sauce made with mayonnaise, sour cream, and a touch of lemon juice, these sandwiches offer a bold kick and rich texture in every bite. Served on toasted hoagie rolls and finished with gooey, melted provolone, this recipe is perfect for game days, casual dinners, or a crowd-pleasing lunch. Easy to make in a slow cooker, these sandwiches are the epitome of comfort food with an Italian twist!

Nutriscore Rating: 62/100

Prep Time:20 mins

Cook Time:480 mins

Total Time:500 mins

Servings: 6

Ingredients

• 3 pounds Beef chuck roast
• 3 cups Beef broth
• 2 tablespoons Dry Italian seasoning mix
• 4 cloves Garlic cloves, minced
• 1 cup Banana pepper rings
• 1 teaspoon Salt
• 0.5 teaspoon Black pepper
• 6 pieces Hoagie rolls or French bread
• 6 slices Provolone cheese slices
• 2 tablespoons Prepared horseradish
• 0.5 cup Mayonnaise
• 2 tablespoons Sour cream
• 1 teaspoon Lemon juice

Directions

Step 1

Heat a large skillet over medium-high heat and sear the beef chuck roast on all sides until browned, about 3-4 minutes per side.

Step 2

Transfer the seared beef to a slow cooker. Add the beef broth, dry Italian seasoning, minced garlic, banana pepper rings, salt, and black pepper.

Step 3

Cover the slow cooker and cook on low for 8 hours, or until the beef is tender and shreds easily with a fork.

Step 4

While the beef is cooking, prepare the horseradish sauce. In a small bowl, stir together the prepared horseradish, mayonnaise, sour cream, and lemon juice until smooth. Refrigerate until ready to use.

Step 5

Once the beef is tender, remove it from the slow cooker and shred it using two forks. Return the shredded beef to the slow cooker to soak up the juices.

Step 6

Preheat your oven to 350°F (175°C). Cut the hoagie rolls in half and lightly toast them in the oven.

Step 7

Place a generous amount of shredded beef on the bottom half of each toasted roll. Top with a slice of provolone cheese.

Step 8

Return the assembled sandwiches to the oven for about 3-5 minutes, or until the cheese is melted.

Step 9

Spread the horseradish sauce on the top half of each roll, then close the sandwiches and serve warm.

Nutrition Facts

Serving size	(3204.9g)

Amount per serving	% Daily Value*
Calories	6524.6

Total Fat 433.1g	0%
Saturated Fat 147.3g	0%
Polyunsaturated Fat 9.4g
Cholesterol 1256.8mg	0%
Sodium 11813.6mg	0%
Total Carbohydrate 322.9g	0%
Dietary Fiber 17.2g	0%
Total Sugars 26.7g
Protein 347.4g	0%

Vitamin D 2.6IU	0%
Calcium 1640.4mg	0%
Iron 54.5mg	0%
Potassium 4924.6mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 59.2%

Protein: 21.1%

Carbs: 19.6%