Grandma B's Southern Cajun Meatloaf

Experience the bold, comforting flavors of the South with Grandma B's Southern Cajun Meatloaf. This classic dish takes a flavorful twist, combining a rich blend of ground beef and pork with finely diced onion, bell pepper, and celery for a savory base. Infused with Cajun seasoning, smoked paprika, and a touch of Worcestershire sauce, every bite bursts with smoky, spiced goodness. A luscious ketchup glaze, sweetened with brown sugar and balanced with apple cider vinegar, bakes to caramelized perfection atop the loaf. Easy to prepare in just 20 minutes and baked to juicy tenderness, this hearty meatloaf is the ultimate crowd-pleasing comfort food. Serve it alongside fluffy mashed potatoes or warm cornbread for a true Southern feast! Perfect for weeknights or family gatherings, this recipe is a must-try for meatloaf lovers seeking a Cajun-inspired twist.

Nutriscore Rating: 65/100

Prep Time:20 mins

Cook Time:60 mins

Total Time:80 mins

Servings: 6

Ingredients

• 1.5 pounds ground beef (80/20 blend)
• 0.5 pounds ground pork
• 1 large yellow onion, finely diced
• 1 medium green bell pepper, finely diced
• 1 medium celery stalk, finely diced
• 4 cloves garlic cloves, minced
• 2 large eggs
• 0.5 cups Panko breadcrumbs
• 0.25 cups whole milk
• 2 tablespoons Worcestershire sauce
• 1.5 tablespoons Cajun seasoning
• 1 teaspoons smoked paprika
• 0.5 teaspoons ground black pepper
• 1 teaspoons kosher salt
• 0.5 cups ketchup
• 1 tablespoons light brown sugar
• 1 teaspoons apple cider vinegar

Directions

Step 1

Preheat your oven to 375°F (190°C). Lightly grease a standard 9x5-inch loaf pan or line it with parchment paper for easy removal.

Step 2

In a large skillet over medium heat, sauté the onion, green bell pepper, and celery in a small drizzle of oil for 5-7 minutes, until softened. Add the minced garlic and cook for another minute. Remove from heat and let cool slightly.

Step 3

In a large mixing bowl, combine the ground beef and ground pork. Add the sautéed vegetables, eggs, Panko breadcrumbs, milk, Worcestershire sauce, Cajun seasoning, smoked paprika, black pepper, and kosher salt. Mix gently with your hands until just combined. Do not overmix.

Step 4

Transfer the meat mixture to the prepared loaf pan and gently press it down to shape it evenly.

Step 5

In a small bowl, mix together the ketchup, brown sugar, and apple cider vinegar to form the glaze. Spread the glaze evenly over the top of the meatloaf.

Step 6

Place the meatloaf in the preheated oven and bake for 50-60 minutes, or until the internal temperature reaches 160°F (71°C).

Step 7

Remove the meatloaf from the oven and let it rest for 10 minutes before slicing and serving. This helps the juices redistribute and keeps the meatloaf moist.

Step 8

Serve warm with your favorite sides, such as mashed potatoes, green beans, or cornbread.

Nutrition Facts

Serving size	(1853.5g)

Amount per serving	% Daily Value*
Calories	3054.8

Total Fat 199.3g	0%
Saturated Fat 76.3g	0%
Polyunsaturated Fat 0.1g
Cholesterol 1065.1mg	0%
Sodium 5583.4mg	0%
Total Carbohydrate 112.9g	0%
Dietary Fiber 14.1g	0%
Total Sugars 58.1g
Protein 197.1g	0%

Vitamin D 151.0IU	0%
Calcium 524.2mg	0%
Iron 22.2mg	0%
Potassium 3360.7mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 59.1%

Protein: 26.0%

Carbs: 14.9%