Easy Southern Chicken Casserole

Transport your taste buds straight to the heart of Southern comfort with this Easy Southern Chicken Casserole. Perfect for busy weeknights or cozy family dinners, this one-dish wonder features tender shredded rotisserie chicken combined with a medley of colorful mixed vegetables and a creamy blend of sour cream and cream of chicken soup. Topped with a golden, buttery biscuit layer made from self-rising flour and buttermilk, this casserole achieves the perfect balance of savory and rich flavors. With just 15 minutes of prep time and a delightful bake that creates beautifully layered textures, this dish is as simple as it is satisfying. Serve it warm and enjoy a crowd-pleasing, soul-soothing meal packed with Southern charm.

Nutriscore Rating: 57/100

Prep Time:15 mins

Cook Time:40 mins

Total Time:55 mins

Servings: 6

Ingredients

• 3 cups shredded rotisserie chicken
• 2 cups frozen mixed vegetables (peas, carrots, corn, and green beans)
• 1 can (10.5 oz) cream of chicken soup
• 1 cup sour cream
• 1 cup unsalted butter, melted
• 1 cup chicken broth
• 1 cup self-rising flour
• 1 cup buttermilk
• 1 teaspoon salt
• 0.5 teaspoon black pepper
• 0.5 teaspoon garlic powder

Directions

Step 1

Preheat your oven to 375°F (190°C) and grease a 9x13-inch baking dish with cooking spray or butter.

Step 2

In a large bowl, combine the shredded rotisserie chicken, frozen mixed vegetables, cream of chicken soup, sour cream, 1/2 cup of melted butter, salt, black pepper, and garlic powder. Mix until well combined.

Step 3

Transfer the chicken and vegetable mixture into the prepared baking dish, spreading it out evenly.

Step 4

In a separate bowl, whisk together the self-rising flour, buttermilk, and the remaining 1/2 cup of melted butter until smooth. This will form your biscuit topping.

Step 5

Pour the biscuit topping mixture evenly over the chicken and vegetable layer in the casserole dish. Do not stir.

Step 6

Pour the chicken broth over the top of the biscuit layer. Again, do not stir; this helps create distinct layers during baking.

Step 7

Place the casserole dish in the preheated oven and bake uncovered for 35-40 minutes, or until the top is golden brown and bubbly.

Step 8

Remove from the oven and let the casserole cool for 5-10 minutes before serving.

Step 9

Serve warm and enjoy a hearty and satisfying Southern classic!

Nutrition Facts

Serving size	(2209.4g)

Amount per serving	% Daily Value*
Calories	4083.5

Total Fat 295.7g	0%
Saturated Fat 171.5g	0%
Polyunsaturated Fat 2.2g
Cholesterol 1123.9mg	0%
Sodium 7065.5mg	0%
Total Carbohydrate 197.9g	0%
Dietary Fiber 17.8g	0%
Total Sugars 54.6g
Protein 165.3g	0%

Vitamin D 200.1IU	0%
Calcium 1190.5mg	0%
Iron 17.2mg	0%
Potassium 2929.6mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 64.7%

Protein: 16.1%

Carbs: 19.2%