Chicken Pepperoni Parmesan Casserole

Elevate your weeknight dinners with this irresistible Chicken Pepperoni Parmesan Casserole—a comforting, flavor-packed dish that combines the best of Italian-American cuisine! Tender, seared chicken breasts are baked under a blanket of zesty marinara sauce, melty mozzarella, and crispy pepperoni slices, all topped with a golden crust of Parmesan cheese and optional seasoned breadcrumbs. The addition of dried oregano and fresh basil garnish brings a fragrant, herbaceous touch, making this casserole as aromatic as it is delicious. Ready in just 50 minutes, this easy-to-make, family-friendly recipe offers all the bold flavors of chicken Parmesan in a hassle-free, one-pan casserole. Perfect for cozy gatherings or hearty weeknight meals, this dish is sure to become a household favorite.

Nutriscore Rating: 61/100

Prep Time:15 mins

Cook Time:35 mins

Total Time:50 mins

Servings: 4

Ingredients

• 4 pieces Chicken breasts (boneless, skinless)
• 1 teaspoon Salt
• 1 teaspoon Black pepper
• 1 teaspoon Garlic powder
• 2 tablespoons Olive oil
• 2 cups Marinara sauce
• 20 pieces Pepperoni slices
• 2 cups Shredded mozzarella cheese
• 1 cup Grated Parmesan cheese
• 0.5 cup Breadcrumbs (optional, for a crispy top)
• 1 teaspoon Dried oregano
• 5 leaves Fresh basil leaves (optional, for garnish)

Directions

Step 1

Preheat your oven to 375°F (190°C).

Step 2

Season the chicken breasts on both sides with salt, black pepper, and garlic powder.

Step 3

Heat olive oil in a large skillet over medium-high heat. Sear the chicken breasts for 2-3 minutes on each side until golden brown (they do not need to cook through at this stage). Remove the chicken from the skillet and set aside.

Step 4

Take a 9x13-inch baking dish and spread 1/2 cup of marinara sauce evenly across the bottom.

Step 5

Place the seared chicken breasts in a single layer over the marinara sauce.

Step 6

Pour the remaining marinara sauce evenly over the chicken breasts.

Step 7

Arrange the pepperoni slices evenly on top of the marinara-covered chicken.

Step 8

Sprinkle shredded mozzarella cheese and grated Parmesan cheese evenly over the pepperoni slices.

Step 9

If using breadcrumbs, mix them with dried oregano and sprinkle the mixture on top of the cheese layer for added crunch.

Step 10

Bake the casserole in the preheated oven for 25-30 minutes, or until the chicken is fully cooked (internal temperature of 165°F or 74°C) and the cheese is golden and bubbling.

Step 11

Remove the casserole from the oven and let it sit for 5 minutes before serving.

Step 12

Garnish with fresh basil leaves before serving for extra flavor and presentation.

Nutrition Facts

Serving size	(1640.6g)

Amount per serving	% Daily Value*
Calories	3114.1

Total Fat 161.0g	0%
Saturated Fat 66.6g	0%
Polyunsaturated Fat 2.7g
Cholesterol 896.5mg	0%
Sodium 7824.1mg	0%
Total Carbohydrate 69.9g	0%
Dietary Fiber 7.1g	0%
Total Sugars 13.7g
Protein 327.9g	0%

Vitamin D 90.5IU	0%
Calcium 2699.8mg	0%
Iron 11.4mg	0%
Potassium 2124.8mg	0%

*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.

Source of Calories

Fat: 47.7%

Protein: 43.1%

Carbs: 9.2%